… early 1960s with the NZB/NZW F1 (NZB/W F1) mouse, an F1 hybrid … CD28 blockade decreased
the production of anti-ds DNA autoantibody, prevented the development of lupus nephritis…

… -term protection from progressive glomerulonephritis for up to … While glomerulonephritis
can still develop in MRL/lpr mice … of IgG1 and can selectively intervene the CD28-CD80/86 …

… Because CD28 signaling triggers glucose metabolism in T cells, we hypothesized that …
development of LN in (NZB × NZW)F1 mice treated at the early stage of disease. This preventive …

… on lupus development. A previous study involving probiotic bacteria in lupus-prone MRL/lpr
mice only addressed prevention … In MLR/lpr mice, B7-1 blockade increases severity of lupus […

… and anti-CD3/CD28 stimulated PBMCs derived from healthy … of lupus nephritis in the NZB/W
F1 mouse model of lupus and … Upon cessation of treatment, mild nephritis developed during …

… corresponding co-stimulatory molecule CD28, which promotes the … At the age of 36 weeks,
all control mice developed … In this study, we treated NZB/NZW F1 mice for several months with …

… , IL-10 is crucial in preventing inflammatory and autoimmune … protects against autoimmune
development by increasing TNF… After 2 days of culture in the presence of α-CD3/CD28 with …

… CD28 blockade prevented the development of LN in NZB/NZW) F1 mice, which have typical
lupus … or anti-CD86 mAb infusion was effective in preventing GVHD-associated mortality by …

… intercross of the classic (NZB×NZW) F1 mice (7) is the … or were stimulated with anti-CD3/CD28–coated
beads for 5 days,… indicator for LN development in spontaneous lupus mice (Figure …

… and may be an effective target for prevention of UVB- … dermoepidermal junction in NZB/NZW
F1 mice exposed to 500 … of young mice accelerated lupus nephritis development, including …